王贵学 教授（二级）博士生导师
长期从事动脉粥样硬化性心脑血管生物力学、生物流变学与血管组织损伤修复材料、纳米药物递送、康复工程等基础研究和应用转化，授权中国和美国专利60余件。入选爱思唯尔中国高被引学者，入选生物医学工程领域全球前2%顶尖科学家年度科学影响力榜单、终身科学影响力榜单（2025），国际生物材料科学与工程会士（FBSE）、中国生物材料学会会士(FCSBM), 国务院特殊津贴专家、重庆市学术带头人。获省部级及国家行业协会科技/教学成果一等奖4项，二三等奖5项、国家科技进步二等奖1项（通过初审公示待颁证）；在Nature Neuroscience, ACS Nano, Journal of Biomechanics, Biomaterials, Bioactive Materials, Research, iMeta, the Innovation, Exploration, Advanced Science, 中国科学, 科学通报等发表中英文学术论文450余篇，主编副主编出版教材专著11部；招收培养博士后25名、博士生60名、硕士生120名。
担任评审专家：国家自然科学基金委杰青/优青/重点/面上/地区/青年/国际合作基金项目、发改委国家医学攻关产教融合创新平台专项、教育部长江学者奖励计划/高等院校青年科学奖及教育教学奖，科技部重点研发计划项目，重庆市科委/发改委/卫健委/教委/人社局科技及人才项目，“科学探索奖”项目评审和提名人。
学术组织任职
担任国际生物材料科学与工程联合会会士/Fellow（FBSE），中国生物材料学会会士/Fellow（FCSBM），中国病理生理学会常务理事兼动脉粥样硬化专业委员会主任委员，中国生物材料学会理事兼材料生物力学分会主任委员，中国解剖学会血管分会名誉主任委员，世界华人生物医学工程协会理事，国家重点研发计划/国家科技支撑计划/国家转基因重大专项课题首席科学家，生物医学工程领域爱思唯尔中国高被引学者/软科国际知名学者（2019-至今），生物医学工程领域全球顶尖前10万名科学家（2019-至今），生物医学工程领域全球前2%顶尖科学家年度科学影响力榜单(World's Top 2% Scientists) （2021-至今）、终身科学影响力榜单（2025），重庆大学二级教授、博导, 生物工程学院原院长/书记/学术委员会主任，重庆大学医学部学术委员会原副主任 ，国家教育部生物流变科学与技术重点实验室原主任，国家教育部高等学校生物医学工程类专业教学指导委员会委员，国家发改委血管植入物开发工程实验室（重庆）创始主任，国家生物产业基地公共实验中心(重庆)创始主任，重庆市发改委血管植入物工程实验室创始主任，重庆大学现代生命科学实验教学中心（重庆市实验教学示范中心）创始主任，四川省高等学校生物科学类专业教学指导委员会副主任委员，国家放射与治疗临床医学研究中心介入医学创新联盟/医工整合联盟副理事长，中国生物医学工程学会生物力学专业委员会委员，中国生物材料学会脑机接口材料分会委员，重庆市中医药行业协会科技分会会长，重庆市脑科学应用学会副会长，国自然重点基金/国家重点研发计划课题/国家科技部国际科技合作重点项目/国家发改委平台建设重大项目等10多项国家级项目主持人，重庆市学术技术带头人/西部（重庆）科学城“金凤凰”杰出人才，国药太极集团科学顾问委员会首批特聘客座专家，Science合作期刊《Research》（IF:11）副主编，《Biomed Mater》（IF:4）和《iMeta》 (IF:33.2)期刊编委。
研究方向
1. 心脑血管生物力学与生物流变学方向。包括从组织、细胞和分子水平上开展的动脉粥样硬化形成的血流动力学成因研究, 血管病变的纳米医药诊治。
2. 细胞分子生物学与基因工程技术方向。包括力-发育生物学、模式动物（斑马鱼、鼠、兔、猪等）生长发育过程中的力学信号感受和响应机制研究。
3. 生物材料与组织修复、微创植介入医疗器械与康复工程方向。包括血管支架、人工血管、心脏瓣膜、脑机接口技术、康复机器人研发等；血管损伤修复的力学生物学机制与防治策略研究。
科研项目
1. 国家重点研发计划项目: 功能化血管/心瓣膜材料与修复体构建关键技术(No. 2023YFB3810100), 3000万元, 2023.11—2026.10, 主持。
2. 国家重点研发计划项目，经导管二二尖瓣植入器械关键技术研究及产品开发应用(No. 2025YFC2423400)，1215万元，2025.11—2028.10，参研。
3. 国家自然科学基金重点项目：血管内皮细胞吞噬促动脉粥样硬化发生的细胞力学生物学机制研究(No.12032007)，370万元，2021.01—2025.12，主持。
4. 国家自然基金面上项目：仿生纳米前药靶向治疗动脉粥样硬化的作用及其力学生物学机制(No. 32471366) ， 50万元，2025.01-2028.12，主持。
5. 金凤实验室科技项目：脑血管病发生的力学生物学机制与精准诊疗研究（No.JFLKYXM202203AZ-211）， 1600万元（其中设备费800万元）， 2022.08-2026.12，主持。
6. 重庆市卫健委重点科技项目: 中医药防治肺癌传承创新团队(渝中医[2022]33), 200万元，2022.11-2026.10，参研.
代表性论文：
1. Yan W, Li S, Zhang T, Huang J, Deng C, Yuan K, Huang N, Zhang H, Wang G. Synergistic fusion of CD47, VE-cadherin and mussel adhesion proteins promotes endothelialization and suppresses inflammation in vascular stents. Bioactive Materials 2026, 55: 257–270, DOI:10.1016/j.bioactmat.2025.09.015（IF:20.3）
2. Deng Z, Xiang Z, Zhu S, Zhang Y, Du Y, Wang S, Kang Z,Wang Z, Tong X, Liu Y, Jiang L, Malashicheva A, Sun H, Dong F, Wang G, Li C, Zang G. Switching Cathodic/Anodic Electrochemiluminescence of Ru(bpy)32+Precisely via Homogeneous Nickel Nanoparticles Crystal Facets Sites Modulated ORR/OER. Exploration, Aug 2025, 20250036, DOI: 10.1002/EXP.20250036, DOI:10.1002/imt2.70048 (IF:22.5)
3. Zeng J, Zhang Y, Gao Y, Jia M, Guo Y, Li X, Wang Y, Zhao C, Qiu J, McGinty S, Miao W, Wang G, Wang Y. Biomimetic Ginsenoside Rb1 and Probucol Co-Assembled Nanoparticles for Targeted Atherosclerosis Therapy via Inhibition of Oxidative Stress, Inflammation, and Lipid Deposition. ACS Nano. 2025 Jul;19(25):22968-22987. DOI: 10.1021/acsnano.5c02492. (IF:16, Nature Index Journal）
4. Wang C；Liu Z, Zhou T, Wu J, Feng F, Wang S, Chi Q, Sha Y, Zha S, Shu S, Qu L, Du Q, Yu H, Yang L, Malashicheva A, Dong N, Xie F, Wang G, Xu K. Gut microbiota‐derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation. iMeta, 2025, e70048. DOI:10.1002/imt2.70048,（IF:33.2, ESI Highly Cited Papers, Hot paper）
5. Shi W, Yi X, Ruan H, Wang D, Wu D, Jiang P, Luo L, Ma X, Jiang F, Li C, Wu W, Luo L, Li L, Wang G, Qiu J, Huang H. An animal model recapitulates human hepatic diseases associated with GATA6 mutations. PNAS-Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2317801121. DOI:10.1073/pnas.2317801121.（IF：9.4, Nature Index Journal）
6. Jia M, Miao M, Li Y, Guo Y, Zeng J, Gao Y, Li X, Wang Y, Zhao Z, Xu Z, Wang Z, Yang F, Zhao J, Wang Y, Wang G. Polymerized probucol nanoformulations with neutrophil extracellular vesicle camouflaging for cerebral ischaemia‒reperfusion injury therapy. The Innovation, 2024, 6(4): 100761, 2025, DOI:10.1016/ j.xinn.2024.100761. (IF:33.2)
7. Liu X, Zhao S, Tan L, Tan Y, Wang Y, Ye Z, Hou C, Xu Y, Liu S, Wang G. Frontier and hot topics in electrochemiluminescence sensing technology based on CiteSpace bibliometric analysis. Biosens Bioelectron. 2022; 201:113932. DOI: 10.1016/j.bios.2021.113932. (IF: 10.618, ESI Highly Cited Papers)
8. Qin X, Zhang K, Qiu J, Wang N, Qu K, Cui Y, Huang J, Luo L, Zhong Y, Tian T, Wu W, Wang Y, Wang G. Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress. Bioact Mater. 2021; 9:397-410 10.1016/j.bioactmat.2021.10.038.89. (IF:16.87).
9. Wang Y, Zhang K, Li T, Maruf A, Qin X, Luo L, Zhong Y, Qiu J, McGinty S, Pontrelli G, Liao X, Wu W, Wang G. Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications. Theranostics, 2021, 11(1): 164-180. DOI: 10.7150/thno.47841. (IF:11.6, ESI Highly cited paper)
10. Zhou T, Zheng Y, Sun L, Badea S, Jin Y, Liu Y, Rolfe A, Sun H, Wang X, Cheng Z, Huang Z, Zhao N, Sun X, Li J, Fan J, Lee C, Megraw T, Wu W, Wang G, Ren Y. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nature Neuroscience. 2019, 22(3), 421–435. DOI:10.1038/s41593-018-0324-9. (IF:21.1, Nature Index Journal, ESI Highly Cited Papers)
11. Wang Y, Zhang K, Qin X, Li T, Qiu J, Yin T, Huang J, McGinty S, Pontrelli G, Ren J, Wang Q, Wu W, Wang G. Biomimetic Nanotherapies: Red Blood Cell Based Core-Shell Structured Nanocomplexes for Atherosclerosis Management. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 2019, 6(12): 1900172. 10.1002/advs.201900172. (IF:15.8, ESI Highly Cited Papers)
12. Bunggulawa J, Wang W, Yin T, Wang N, Durkan C, Wang Y, Wang G. Recent advancements in the use of exosomes as drug delivery systems. Journal of Nanobiotechnology. 2018, 16(1), 81. DOI: 10.1186/s12951-018-0403-9. (IF:10.43, ESI Highly Cited Papers)
代表性专利、标准
1. 徐紫宸; 王贵学; 徐文峰; 廖晓玲; A DEVICE FOR VASCULAR HEMODYNAMIC BIONIC CELL EXPERIMENT AND METHODS FOR USING THE SAME, 美国, 2017-10-10, U.S.9784662B2.
2. 王贵学 ;罗力 ;吴伟 ;尹铁英 ;刘元莉 ;王溢; 生物可降解示踪材料及其制备方法和应用,2021-03-30,中国，ZL201810498500.0
3. 王贵学; 叶志义; 董文秀; 席亚东; 吴海德; 一种基于静电纺丝的小口径人工血管制备装置, 2017-8-22, 中国, ZL201610203718.X.
4. 王贵学; 杜若林; 尹铁英; 王亚洲; 饶琼; 一种核壳结构纳微粒涂层血管支架及其制备方法, 2016-1-13, 中国, ZL201310350012.2.
5. 王贵学; 孙大明; 尹铁英; 血管内支架涂层制备装置, 2016-12-7,中国, ZL201320363717.3.
代表性专著和教材
担任主编 6 本教科书，担任副主编 1 本教科书，撰写 2 个教科书章节；担任主编 2 部专著，担任副主编 2 部专著，撰写 6 个专著章节，其中包括：
王贵学著.《The Mechanobiology in Atherosclerosis: Basic, Frontier and Advance》（in English），Singapore：Springer Nature Singapore，2024.
王贵学主编. 《临床研究方法》，北京：电子工业出版社，2025，国家高等学校生物医学工程类教学指导委员会规划教材.
王贵学主编. 《生物医学统计学》，北京：电子工业出版社，2024，国家高等学校生物医学工程类教学指导委员会规划教材，ISBN：978-7-121-47465-1，2024
李关荣，王贵学 主编. 《高级生物化学》（第2版）, 重庆: 西南师范大学出版社, 2021，普通高等学校规划教材-生命科学类.
王贵学著.《动脉粥样硬化的力学生物学基础与前沿》，重庆: 重庆大学出版社，2020.
王贵学主编. 《生物工程综合大实验》，北京：科学出版社，2013.
李关荣，王贵学 主编. 《高级生物化学》, 重庆: 西南师范大学出版社, 2010，高等学校规划教材
王贵学等副主编. 《中国教育质量保障与评估》, 北京：国家行政学院出版社，2009, 主编: 罗佐杰.
李关荣，王贵学 主编. 《生物专业英语》, 重庆：西南师范大学出版社，2007.
王贵学主编. 园艺试验与统计分析, 成都: 成都科技大学出版社, 1994.
王贵学, 刘伯彬主编. 《宇宙全息探索》, 出版社: 成都科技大学出版社, 1993.10.
王贵学，邱菊辉编著.《细胞在材料表面的黏附与铺展》，见尹光福、张胜民主编. 《生物医学材料学 材料生物学》（第4章），pp.47-59，人民卫生出版社，2021，国家卫健委“十三五”规划教材，教育部生物医学工程专业教学指导委员会“十三五”规划教材.
王贵学等. Advances in hemodynamics, lipid concentration polarization and atherosclerosis. In “Advances in Atherosclerosis Research” 2012: ISBN: 978-81-308-0498-9, Research Signpost, Kerala, India. Editors: Yong-Zong Yang, Ming Zhao and Ke-Seng Zhao.
王贵学编著. 血流动力学变化与动脉粥样硬化, 见杨永宗主编: 《动脉粥样硬化性心血管病基础与临床》（第 32章）, 北京：科学出版社，2009 （第二版）.
王贵学编著. 动脉粥样硬化与血流动力学变化，见杨永宗主编：《动脉粥样硬化性心血管病基础与临床》（第25章）, 北京: 科学出版社, 2004.
王贵学，王瑾瑄编著. 《动脉粥样硬化与血管支架介入治疗的力学生物学》,见姜宗来、齐颖新主编：《血管力学生物学》（第20章），pp.625-657, 上海交通大学出版社，2018.
王贵学，王瑾瑄，黄玉华，赵银瓶编著.《血管支架内皮化与内皮损伤修复的力学生物学》，见杨力、吕永钢主编. 《组织修复生物力学》（第10章），pp.235-266，上海交通大学出版社，2018.
招生专业及方向
博士后及博士研究生：生物医学工程：1. 生物力学与组织修复；2. 纳米技术与生物材料；3. 智能医学工程；生物学：1. 生物化学与分子生物学；2. 细胞信号与基因调控；3. 发育生物学；
硕士研究生：生物医学工程：1. 生物力学与组织修复；2. 纳米技术与生物医药；3. 生物医学传感检测与医疗仪器；生物学：1. 分子生物学与基因工程；2. 生物信息学；3. 分子与纳米生物技术；生物与医药：1. 生物材料与植介入器械；2. 生物医药工程与转化；3. 智能医学技术与系统。
Guixue Wang
【TITLE & POSITION】
Ph.D., Senior Professor, FBSE, FCSBM.
Member of the Teaching Steering Committee for Biomedical Engineering in Colleges
and Universities, Ministry of Education, China (October 2018–present)
Deputy Director of the Academic Committee of Chongqing University Health Science Center (December 2019 - December 2023)
Director, Key Laboratory of Biorheological Science and Technology, Ministry of
Education, China (June 2018–February 2025)
Founding Director, National Local Engineering Laboratory in Vascular Implants, National Development and Reform Commission, China (March 2015– present)
Founding Director, Public Experiment Center of National Biological Industrialization Base (Chongqing), National Development and Reform Commission, China (August 2008 – present)
Founding Director, Chongqing Engineering Laboratory in Vascular Grafts, Chongqing, China (December 2008 – December 2018)
Founding Director, Construction Base of National First-Class Characteristic Specialty in Biological Engineering, Ministry of Education, China (September 2008 - December 2012)
Associate Dean, National “985 Project” Institute of Biorheology and Gene Regulation Technique, Chongqing University, China (June 2005—May 2008)
Deputy Dean，Dean/Chairperson, College of Bioengineering, Chongqing University, China (July 2002 – April 2023)
Founding Director, Research Center of Applied Biotechnology, Chongqing University, China (January 2002 –December 2008)
September 2000—present, Professor, College of Bioengineering, Chongqing University, China
【HONORARY TITLES】
Fellow (FCSBM): Fellow of the Chinese Society for Biomaterials (2025.09-)
Fellow (FBSE): Fellow of the International Union of Societies for Biomaterials Science and Engineering (2024.5-)
World's Top 2% Scientists (Single Year, 5 times, 2021--2025) in Biomedical Engineering.
World's Top 2% Scientists (Career Long, 2025) in Biomedical Engineering.
ELSEVIER Highly Cited Chinese Researchers (RANKING Internationally Famous Scholars) in Biomedical Engineering (6 times, 2019--2024) in Biomedical Engineering.
GLOBALAUTHORID 2023 One of the World's Top 100000 Scientists (6 times, 2019--2024) in Biomedical Engineering.
Chongqing Academic and Technical Leader (2019-).
Young and Middle-aged Key Teachers of Colleges and Universities in Chongqing (2007-).
【ACADEMIC APPOINTMENTS】
Honorary Chairperson: Vascular Branch of the Chinese Society of Anatomy (2023.12 -)
Chairperson: Branch of Atherosclerosis under the Chinese Society of Pathophysiology (2021.06 -)
Chairperson: Material Biomechanics Branch of the Chinese Society for Biomaterials (2022.12 -)
Chairperson: Science and Technology Branch of Chongqing Traditional Chinese Medicine Industry Association, China (2019.01-)
Life Member: World Association for Chinese Biomedical Engineers (2016-), International Chinese Musculoskeletal Research Society (ICMRS) (2019.04 -)
Vice Chairperson: The Interventional Medicine Innovation Alliance of the National Radiology and Therapy Clinical Medical Research Center (2022.12-), Vascular Branch of Chinese Society of Anatomy (2018.9 -); Professional Committee of Interventional Medicine Engineering and Biotechnology, the Interventional Medicine Branch of the Chinese Medical Doctor Association (2018.06 -), Chinese Holistic Integrative Medicine and Engineering Alliance (2018.01-)
Executive Member of the Council: Branch of Interventional Treatment of Cardiac and Brain Diseases, China Medical Device Industry Association (2017.03--2021.03), Branch of Interventional Medical Engineering of Chinese Society of Biomedical Engineering (2007.08--2015.05), Cardiovascular Biomaterials Branch of Chinese Society for Biomaterials (2015.06-), China Branch of International Society of Atherosclerosis (2015.01-), Chongqing Biomedical Engineering Association (2006.01-).
Member of Council:, World Association for Chinese Biomedical Engineers (2024.07-), Chinese Society of Biomedical Engineering (2015.12--2019.12), Chinese Society for Biomaterials (2012.06-), the Intellectual Medical Professional Committee of the Chinese Medical Doctor Association (2018.05-), Branch of Biomechanics under Chinese Society of Biomedical Engineering and Chinese Society of Mechanics (2015.03-), Branch of Rehabilitation Engineering under Chinese Society of Biomedical Engineering (2016.07-), China Branch of International Society of Atherosclerosis (2011.04--2014.12), Branch of Zebrafish under Chinese Society of Animals (2016.09-)
Associate/Deputy Editor: Research (2024.02-), Molecular & Cellular Biomechanics (2020-), Journal of Medical and Biological Engineering (2018--2022)
Executive Member of the Editorial Board: Chinese Journal of Arteriosclerosis (2014-)
Editorial Board Members: iMeta (2025-), Biomedical Materials (2021-), Molecular & Cellular Biomechanics (2017-), Journal of Medical and Biological Engineering (2014-), AIMS Bioengineering (2014-2018), Journal of Cardiology Therapy (2014-2018), Chinese Journal of Arteriosclerosis (2009--2014)
Guest Editor-in-Chief: Frontiers in Pharmacology, Special Issue: Bioactive Substance-Mediated Targeted Therapy for Cardio-Cerebrovascular Diseases (2022)
【CONTACT INFORMATION】
Tel: 86-23-65106996(O), Fax: 86-23-65102507
Email: wanggx@cqu.edu.cn
http://bio.cqu.edu.cn/info/1164/3021.htm
【PERSONAL PROFILE】
Prof. Guixue WANG has long been engaged in basic research and applied transformation in areas such as the biomechanics of atherosclerotic cardiovascular and cerebrovascular diseases, biorheology and vascular tissue repair materials, nanomedicine delivery, and rehabilitation engineering and has been granted more than 60 Chinese and US patents. He was selected as a World's top 2% scientist (Single Year, 5 times, 2021--2025, and Career Long, 2025) in Biomedical Engineering by Elsevier. He is a Fellow of the Chinese Society for Biomaterials (FCSBM) and a Fellow of the International Union of Societies for Biomaterials Science and Engineering (FBSE). He is a recipient of the State Council Special Government Allowance and an academic leader in Chongqing, China. He has received four first prizes, five second and third prizes for provincial and ministerial-level and national industry association science and technology/teaching achievements, and one second prize for the National Science and Technology Progress Award (passed the preliminary review and public announcement, awaiting certificate issuance). He has published over 450 academic papers in Chinese and English in journals such as Nature Neuroscience, ACS Nano, Journal of Biomechanics, Biomaterials, Bioactive Materials, Research, iMeta, The Innovation, Exploration, Advanced Science, Science in China, and Science Bulletin. He has also edited or coedited 11 textbooks and monographs. He has supervised and trained 30 postdoctoral fellows, 60 doctoral students, and 120 master's students.
He has also selected as a Review Expert for the National Natural Science Foundation of China (NSFC) Outstanding Young Scientists Fund/Excellent Young Scientists Fund/Key Project/General Project/Regional Project/Youth Project/International Cooperation Project; the NSFC Thousand Talents Program; the NDRC National Medical Research and Development Innovation Platform Project; the Ministry of Education Changjiang Scholars Program/Higher Education Institutions Young Scientist Award and Teaching Award; the Ministry of Science and Technology Key Research and Development Program; the Chongqing Municipal Science and Technology Commission/NDRC/Health Commission/Education Commission/Human Resources and Social Security Bureau Science and Technology and Talent Projects; and the Reviewer and nominator for the "Science Exploration Award" project.
【RESEARCH INTERESTS】
Biomedical Engineering, Biochemistry & Molecular Biology, Biomechanics, Biomedical materials, Cell Biology, Materials Science, Atherosclerosis, Basic and clinical translational sciences, Minimally invasive medical devices, Nanodrug delivery, Nanoscience & Nanotechnology.
【REPRESENTATIVE RESEARCH PROJECTS】
A total of 47 projects at all levels have been undertaken. There were 13 projects at the national level, 28 at the provincial, ministerial, and municipal levels, and 4 horizontally. Research funding of over 70 million yuan was received, including the following most recent year projects:
“Study the effects of biomimetic nanoprodrugs on targeted anti-atherosclerosis and their mechanobiology mechanisms”. Supported by the National Natural Science Foundation of China (No. 32471366), 2025.01-2028.12, as principal investigator, 500,000 RMB
“Key Technologies for Functionalized Vascular/Heart Valve Materials and Prosthesis Construction” Supported by National Key R&D Program Projects, China (No.2023YFB3810100), 2023.11-2026.10. 30,000,000 RMB
“Study on the Mechanobiological Mechanism and Precise Diagnosis and Treatment of Cerebrovascular Diseases”, Supported by Science and Technology Innovation Project of JinFeng Laboratory (Chongqing), China (No. jfkyjf202203001), 2022.09-2026.08. 8,000,000 RMB
“Study on Cellular Mechanobiology Mechanism of Engulfment of Vascular Endothelial Cell Promoting Atherosclerosis”, Supported by Key Projects of the National Natural Science Foundation of China (No. 12032207), 2021.01-2025.12. 3,700,000 RMB
“The Role and Mechanism of Low and Oscillatory Shear Stress-downregulated TET1s Promoting Atherosclerosis Development”, Supported by the National Natural Science Foundation of China (No. 31971242), 2020.01-2023.12. 700,000 RMB
“The 7th Sino US Biomedical Engineering and Biomechanics at Home and Abroad Technical Seminar”, Supported by the Emergency Management Project of National Natural Science Foundation of China (No.11842023), 2019.07.26-2019.07.30. 8,0000 RMB.
“Study on Phenotypic Regulation and Reverse Calcification Technology during Degradation Control of Vascular Endothelial and Smooth Muscle Cell”, Supported by the National Key Technology R&D Program (No. 2016YFC1102305), 2016.01-2020.12. 1,500,000 RMB
“Mechano-Biological Mechanism Which Flow Shear Stress Regulates Vascular Development in Zebrafish”, Supported by the National Natural Science Foundation of China (No. 11572064), 2016.01-2019.12, 860,000 RMB
“Mechano-Biological Mechanism on In-stent Restenosis and Late Thrombosis Reduced by Mechanic Environments after Intravascular Stent Implanting”, Supported by Key Projects of the National Natural Science Foundation of China (No. 11332003), 2014.01-2018.12, as coprincipal investigator, 1,500,000 RMB
“Mechano-Biological Mechanism underlying High Shear Stress-Promoted Angiogenesis-Induced Vulnerable Plaque Formation”, Supported by the National Natural Science Foundation of China (No. 31370949), 2013.01-2017.12. 820,000 RMB
“The Effect and Mechanism of Mussel Protein/VE-cadherin/CD47 Fusion Protein Coating on Promoting Vascular Injury Repair”, Supported by Key Projects of the Natural Science Foundation of Chongqing Science and Technology Bureau (No. cstc2019jcyj-zdxmX0028), 2019.09- 2022.08. 800,000 RMB
【REPRESENTATIVE PUBLICATIONS】
Professor Wang has collaborated with domestic and foreign scholars to publish over 400 peer-reviewed papers in total. Some representative papers are as follows.
1. Yan W, Li S, Zhang T, Huang J, Deng C, Yuan K, Huang N, Zhang H, Wang G. Synergistic fusion of CD47, VE-cadherin and mussel adhesion proteins promotes endothelialization and suppresses inflammation in vascular stents. Bioactive Materials 2026, 55: 257–270, DOI:10.1016/j.bioactmat.2025.09.015（IF:20.3）
2. Deng Z, Xiang Z, Zhu S, Zhang Y, Du Y, Wang S, Kang Z,Wang Z, Tong X, Liu Y, Jiang L, Malashicheva A, Sun H, Dong F, Wang G, Li C, Zang G. Switching Cathodic/Anodic Electrochemiluminescence of Ru(bpy)32+Precisely via Homogeneous Nickel Nanoparticles Crystal Facets Sites Modulated ORR/OER. Exploration, Aug 2025, 20250036, DOI: 10.1002/EXP.20250036, DOI:10.1002/imt2.70048,(IF:22.5)
3. Zeng J, Zhang Y, Gao Y, Jia M, Guo Y, Li X, Wang Y, Zhao C, Qiu J, McGinty S, Miao W, Wang G, Wang Y. Biomimetic Ginsenoside Rb1 and Probucol Co-Assembled Nanoparticles for Targeted Atherosclerosis Therapy via Inhibition of Oxidative Stress, Inflammation, and Lipid Deposition. ACS Nano. 2025 Jul;19(25):22968-22987. DOI: 10.1021/acsnano.5c02492. (IF:16, , Nature Index Journal）
4. Wang C；Liu Z, Zhou T, Wu J, Feng F, Wang S, Chi Q, Sha Y, Zha S, Shu S, Qu L, Du Q, Yu H, Yang L, Malashicheva A, Dong N, Xie F, Wang G, Xu K. Gut microbiota‐derived butyric acid regulates calcific aortic valve disease pathogenesis by modulating GAPDH lactylation and butyrylation. iMeta, 2025, e70048. DOI:10.1002/imt2.70048,（IF:33.2, ESI Highly Cited Papers, Hot paper）
5. Shi W, Yi X, Ruan H, Wang D, Wu D, Jiang P, Luo L, Ma X, Jiang F, Li C, Wu W, Luo L, Li L, Wang G, Qiu J, Huang H. An animal model recapitulates human hepatic diseases associated with GATA6 mutations. PNAS-Proc Natl Acad Sci U S A. 2025 Jan 7;122(1):e2317801121. DOI:10.1073/pnas.2317801121.（IF：9.4, Nature Index Journal）
6. Jia M, Miao M, Li Y, Guo Y, Zeng J, Gao Y, Li X, Wang Y, Zhao Z, Xu Z, Wang Z, Yang F, Zhao J, Wang Y, Wang G. Polymerized probucol nanoformulations with neutrophil extracellular vesicle camouflaging for cerebral ischaemia‒reperfusion injury therapy. The Innovation, 2024, 6(4): 100761, 2025, DOI:10.1016/ j.xinn.2024.100761. (IF:33.2)
7. Liu X, Zhao S, Tan L, Tan Y, Wang Y, Ye Z, Hou C, Xu Y, Liu S, Wang G. Frontier and hot topics in electrochemiluminescence sensing technology based on CiteSpace bibliometric analysis. Biosens Bioelectron. 2022; 201:113932. DOI: 10.1016/j.bios.2021.113932. (IF: 10.618, ESI Highly Cited Papers)
8. Qin X, Zhang K, Qiu J, Wang N, Qu K, Cui Y, Huang J, Luo L, Zhong Y, Tian T, Wu W, Wang Y, Wang G. Uptake of oxidative stress-mediated extracellular vesicles by vascular endothelial cells under low magnitude shear stress. Bioact Mater. 2021; 9:397-410 10.1016/j.bioactmat.2021.10.038.89. (IF:16.87).
9. Wang Y, Zhang K, Li T, Maruf A, Qin X, Luo L, Zhong Y, Qiu J, McGinty S, Pontrelli G, Liao X, Wu W, Wang G. Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications. Theranostics, 2021, 11(1): 164-180. DOI: 10.7150/thno.47841. (IF:11.6, ESI Highly cited paper)
10. Zhou T, Zheng Y, Sun L, Badea S, Jin Y, Liu Y, Rolfe A, Sun H, Wang X, Cheng Z, Huang Z, Zhao N, Sun X, Li J, Fan J, Lee C, Megraw T, Wu W, Wang G, Ren Y. Microvascular endothelial cells engulf myelin debris and promote macrophage recruitment and fibrosis after neural injury. Nature Neuroscience. 2019, 22(3), 421–435. DOI:10.1038/s41593-018-0324-9. (IF:21.1, Nature Index Journal, ESI Highly Cited Papers)
11. Wang Y, Zhang K, Qin X, Li T, Qiu J, Yin T, Huang J, McGinty S, Pontrelli G, Ren J, Wang Q, Wu W, Wang G. Biomimetic Nanotherapies: Red Blood Cell Based Core-Shell Structured Nanocomplexes for Atherosclerosis Management. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 2019, 6(12): 1900172. 10.1002/advs.201900172. (IF:15.8, ESI Highly Cited Papers)
12. Bunggulawa J, Wang W, Yin T, Wang N, Durkan C, Wang Y, Wang G. Recent advancements in the use of exosomes as drug delivery systems. Journal of Nanobiotechnology. 2018, 16(1), 81. DOI: 10.1186/s12951-018-0403-9. (IF:10.43, ESI Highly Cited Papers)
【REPRESENTATIVE MONOGRAGHES】
Accumulated: 6 textbooks as an editor-in-chief; 1 deputy editor, 2 textbook chapters; 2 monographs as an editor-in-chief, 2 monograph as deputy editor, and 6 monograph chapters, including:
Wang G. “The Mechanobiology in Atherosclerosis: Basic, Frontier and Advance”（in English），Singapore：Springer Nature Singapore，2024.
“Clinical Research Methods”, Beijing: Electronic Industry Press, 2025, a textbook planned by the National Universities Biomedical Engineering Teaching Steering Committee. Editor-in-Chief: Wang G
“Biomedical Statistics”, Beijing: Electronic Industry Press, 2024, a textbook planned by the National Universities Biomedical Engineering Teaching Steering Committee. Editor-in-Chief: Wang G
“Advanced Biochemistry” (2nd Edition), Chongqing: Southwest Normal University Press, 2021. Co-Editor-in-Chief: Wang G
“Mechanobiological Basis and Frontiers of Atherosclerosis”, Chongqing University Press, 2020, A monograph reflecting the summary of the research results of Professor Wang and his team engaged in the mechanobiology of atherosclerosis for more than 20 years. Editor: Wang G
“Comprehensive Experiments of Bioengineering”, Beijing: Science Press, 2013. Editor-in-Chief: Wang G
“Advanced Biochemistry”, Chongqing: Southwest Normal University Press, 2010, Co-Editor-in-Chief: Wang G
“China Education Quality Assurance and Evaluation”, Beijing: National Academy of Administration Press, 2009, Associate Editor-in-Chief: Wang G
“Professional English for Biology”, Chongqing: Southwest Normal University Press, 2007, Co-Editor-in-Chief: Wang G
“Horticultural Experiments and Statistical Analysis”, Chengdu: Chengdu University of Science and Technology Press, 1994. Editor-in-Chief: Wang G
“Cosmic Holographic Exploration”, Chengdu: Chengdu University of Science and Technology Press, 1993, Editor-in-Chief: Wang G
Wang G, Qiu J. Adhesion and spreading of cells on the surface of materials. In “Biomedical Materials Science--Materials Biology” (Ch 4), Beijing: People's Health Publishing House, 2021. Editors: Guangfu Yin and Shengmin Zhang.
Wang G, et al. Advances in hemodynamics, lipid concentration polarization and atherosclerosis. In “Advances in Atherosclerosis Research” 2012: ISBN: 978-81-308-0498-9, Research Signpost, Kerala, India. Editors: Yong-Zong Yang, Ming Zhao and Ke-Seng Zhao.
Wang G. Hemodynamic changes and atherosclerosis. In “Atherosclerotic Cardiovascular Disease Basics and Clinics” (Ch 32), Beijing: Science Press, 2009 (Second Edition) Editor-in-Chief: Yongzong Yang.
Wang G. Atherosclerosis and hemodynamic changes. In “Atherosclerotic Cardiovascular Disease Basics and Clinics”" (Ch 25), Beijing: Science Press, 2004 (First Edition) Editor-in-Chief: Yongzong Yang.
Wang G, et al.The Mechanobiology of Atherosclerosis and Interventional Therapy of Vascular Stents. In “Mechanobiology” (Ch 20), Shanghai Jiaotong University Publishing House. 2018. Editors: Zonglai Jiang and Yingxin Qi.
Wang G, et al. The Mechanobiology of Vascular Stent Endothelialization and Endothelial Injury Repair. In “Tissue Repair Biomechanics” (Ch 10), Shanghai Jiaotong University Press. 2018. Editors: Li Yang and Yonggang Lv.
