吴伟，男，讲师，硕士生导师。生于1985年12月，籍贯四川遂宁。

主要研究方向：

（一）仿生智能纳米药物的设计与研究：通过优化智能响应（如pH、氧化还原、热、光等）作用赋予纳米药物靶向递送及可控释放的性能，以满足其在不同递送阶段（血液循环、靶向聚集、组织滞留及渗透、细胞摄取、胞内药物控释等）相应的物化特性需求，实现高效用、低毒副作用疾病治疗应用研究。

（二）全降解聚合物心脑血管支架的研究：通过全降解聚合物支架的降解控制技术，优化其在体内的降解进程，增加全降解血管支架临床适用性及生物相容性，降低血管支架再狭窄及血栓形成风险，为全降解聚合物心脑血管支架的临床应用研发奠定理论基础。

学习经历：

2006.09-2010.06  青岛科技大学高分子科学与工程学院 包装工程专业      学士

2010.09-2015.06  四川大学高分子科学与工程学院     生物医学工程专业  硕、博士

工作经历：

2015.07-至今 重庆大学生物工程学院 讲师

2015.11-至今 重庆大学生物工程学院 博士后（合作导师：王贵学教授）

联系方式：重庆大学B区生物技术研究中心402办公室

邮箱(E-mail)：david2015@cqu.edu.cn

研究成果：

（一）学术论文：（IF更新至2016.09.07）

1.Wu, W., Wang W., Li, J.,* Star polymers: Advances in biomedical applications. Progress in Polymer Science, 46, 55-85，2015. (IF: 27.184)

2.Wu, W., Zhang, Q., Wang, J., Chen, M., Li, S., Lin, Z., Li, J.,* Tumor-targeted aggregation of pH-sensitive nanocarriers for enhanced retention and rapid intracellular drug release. Polymer Chemistry, 5, 5668-5679, 2014. (IF: 5.687 )

3.Wu, W., Wang, J., Lin, Z., Li, X., Li, J.,* Tumor-acidity activated surface charge-conversion of polymeric nanocarriers for enhanced cell adhesion and targeted drug release. Macromolecular Rapid Communications, 35, 1679-1684, 2014. (IF: 4.638)

4.Wu, W., Wang, W., Li, S., Wang, J., Zhang, Q., Li, X., Luo, X., Li, J.,* Physiological pH-triggered morphological transition of amphiphilic block copolymer self-assembly. Journal of Polymer Research, 21, 494, 2014. (IF: 1.969 )

5.Wu, W., Chen, M., Wang, J., Zhang, Q., Li, S., Li, Z., Li, J.,* Nanocarriers with dual pH-sensitivity for enhanced tumor cell uptake and rapid intracellular drug release. RSC Advances, 4, 30780-30783, 2014. (IF: 3.289)

6.Wu, W., Liu, J., Cao, S., Tan, H., Li, J.,* Xu, F., Zhang, X., Drug release behaviors of a pH sensitive semi-interpenetrating polymer network hydrogel composed of poly(vinyl alcohol) and star poly[2-(dimethylamino)ethyl methacrylate]. International Journal of Pharmaceutics, 416, 65-72, 2016. (IF: 3.994 )

7.Wu, W. ,†（共同一作） Ye, C.,† Xiao, H.,† Sun, X., Qu, W., Li, X., Chen, M.,* Li, J.,* Hierarchical mesoporous silica nanoparticles for tailorable drug release. International Journal of Pharmaceutics, 511, 104-109, 2011. (IF: 3.994 )

8.Li, S.,† Wu, W.,†（共同一作）Xiu, K., Xu, F., Li, Z.,* Li, J.,* Doxorubicin loaded pH-responsive micelles capable of rapid intracellular drug release for potential tumor therapy. Journal of Biomedical Nanotechnology, 10, 1480-1489, 2014. (IF: 3.929)

9.Chen, T.,† Wu, W.,†（共同一作） Xiao, H.,† Chen. Y., Chen, M., Li, J.,* Intelligent Drug Delivery System Based on Mesoporous Silica Nanoparticles Coated with an Ultra-pH-Sensitive Gatekeeper and Poly(ethylene glycol), ACS Macro Letters, 10, 55-58, 2016. (IF: 5.766)

10.Li, S.,† Zhao, Z.,† Wu, W.,†（共同一作）Ding, C., Li, J.,* Dual pH-responsive micelles with both charge-conversional property and hydrophobic-hydrophilic transition for effective cellular uptake and intracellular drug release. Polymer Chemistry, 7, 2202-2208, 2016. (IF: 5.687 )

11.Li, R.Q.,† Wu, W.,† Song, H.Q., Ren, Y., Yang, M., Li, J.,* Xu, F. J.,* Well-defined reducible cationic nanogels based on functionalized low-molecular-weight PGMA for effective pDNA and siRNA delivery. Acta Biomaterialia, 41, 282-292, 2016. (IF: 6.008)

12.Li, X., Shang, H., Wu, W.*（共同通讯） Li, S., Lin, Z., Duan, J., Xu, L., Li J.,* Glucose-Responsive Micelles for Controlled Insulin Release Based on Transformation from Amphiphilic to Double Hydrophilic. Journal of Nanoscience and Nanotechnology, 16, 5457-5463, 2016. (Accepted ; IF: 1.338)

13.Chen, X., Wu, W., Guo, Z., Xin, J., Li, J.,* Controlled insulin release from glucose-sensitive self-assembled multilayer films based on 21-arm star polymer. Biomaterials, 32, 1759-1766, 2011. (IF: 8.557)

14.He, Q., Wu, W., Xiu, K., Zhang, Q., Xu, F., Li, J.,* Controlled drug release system based on cyclodextrin-conjugated poly(lactic acid)-b-poly(ethylene glycol) micelles. International Journal of Pharmaceutics, 443, 110-119, 2013. (IF: 3.994 )

15.Chen, X., Luo, J., Wu, W., Tan, H., Xu, F., Li, J.,* The influence of arrangement sequence on the glucose-responsive controlled release profiles of insulin-incorporated LbL films. Acta Biomaterialia, 8, 4380-4388, 2012. (IF: 6.008)

16.Luo, J., Cao, S., Chen, X., Liu, S., Tan, H., Wu, W., Li, J.,* Super long-term glycemic control in diabetic rats by glucose-sensitive LbL films constructed of supramolecular insulin assembly. Biomaterials, 33, 8733-8742, 2012. (IF: 8.557)

17.Yang, J., Cao, S., Xin, J., Chen, X., Wu, W., Li, J.,* Calcium carbonate deposition on layer-by-layer systems assembled from star polymers. Journal of Polymer Research, 20, 157, 2013. (IF: 1.969 )

18.Yang, J., Cao, S., Li, J., Xin, J., Chen, X., Wu, W., Xu, F., Li, J.,* Staged self-assembly of PAMAM dendrimers into macroscopic aggregates with a microribbon structure similar to that of amelogenin. Soft Matter, 9, 7553-7559, 2013. (IF: 3.798)

19.Li, J., Yang, J., Li, J., Chen, L., Liang, K., Wu, W., Chen, X., Li, J.,*  Bioinspired intrafibrillar mineralization of human dentine by PAMAM dendrimer. Biomaterials, 34, 6738-6747, 2013. (IF: 8.557)

20.Lin, Z., Cao, S., Chen, X., Wu, W., Li, J.,* Thermoresponsive hydrogels from phosphorylated ABA triblock copolymers: a potential scaffold for bone tissue engineering. Biomacromolecules, 14, 2206-2214, 2013. (IF: 5.583)

21.Wu, D., Yang, J., Li, J., Chen, Li., Tang, B., Chen, X., Wu, W., Li, J.,*  Hydroxyapatite-anchored dendrimer for in situ remineralization of human tooth enamel. Biomaterials, 34, 5036-5047, 2013. (IF: 8.557)

22.Liu, S., Chen, X., Zhang, Q., Wu, W., Xin, J., Li, J.,* Multifunctional hydrogels based on β-cyclodextrin with both biomineralization and anti-inflammatory properties. Carbohydrate Polymers, 102,869-876, 2014. (IF: 4.219)

23.Li, S., He, Q., Chen T., Wu, W., Lang, K., Li, Z.,* Li, J.,* Controlled co-delivery nanocarriers based on mixed micelles formed from cyclodextrin-conjugated and cross-linked copolymers. Colloids and Surfaces B: Biointerfaces, 123, 486-492, 2014. (IF:3.902)

24.Chen, X., Chen, T., Lin, Z., Li, X., Wu, W., Li, J.,* Choline phosphate functionalized surface: protein-resistant but cell-adhesive zwitterionic surface potential for tissue engineering. Chemical Communications, 51, 487-490, 2015. (IF: 6.567)

25.Wu, D., Chen, X., Chen, T., Ding, C., Wu, W., Li, J.,* Substrate-anchored and degradation-sensitive anti-inflammatory coatings for implant materials. Scientific Reports, 5, 11105, 2015. (IF: 5.228)

（二）会议论文

1.Wu, W., Wu D., Li S., Lin Z., Li, J.,* Doxorubicin loaded pH-sensitive micelles for potential tumor therapy. Journal of Controlled Release, e72–e73, 2013. (国际会议论文; IF: 7.441  )

2.Wu, W., Li S., Lin Z., Li, J.,* pH-sensitive nanocarriers for enhanced tumor retention and rapid intracellular drug release. Journal of Controlled Release, 2015, 213, e122-e123. (国际会议论文; IF: 7.441  )

3.Wu, W.,†（共同一作） Ye, C.,† Chen, M.,*  Li, J.,* Sophisticated mesoporous silica nanoparticles for controlled drug release. Nanomedicine: Nanotechnology, Biology and Medicine, 2016, 1(2), 556. (国际会议论文; IF: 5.671)

4.吴伟，贺琴，陈星羽，李建树，*基于星形聚合物的 pH 敏感半互穿网络水凝胶药物控释研究，2011年高分子学术论文报告会,  661, 2011. (会议论文)

5.Wu, W., Wang, G.,* Li, J.,* Dual pH-sensitive nano-micelle for anti-tumor drug delivery, 第十三次全国动脉硬化性疾病学术会议, 2015, 海口.（国内会议论文）

6.Li, X., Wu, W., Li, J.,* Glucose-responsive micelles for insulin release. Journal of Controlled Release, 2015, 213, e111-e112. (国际会议论文; IF: 7.441  )

7.凌博，张康，张涛，尹铁英，叶志义，吴伟，王贵学，*高切应力和高脂调控血管新生对动脉粥样易损斑块形成的影响，第十三次全国动脉硬化性疾病学术会议，2015.（会议论文）

（三）主持科研项目：

1.四川省科技创新苗子工程，基于多肽-降钙素超分子聚集体构建的长效缓释新剂型，2015/07 -2016/06，3万 ；

2.中央高校基本科研业务费学院科技型专项，光激活表面电位反转纳米前药抗肿瘤的研究，2016/01-2017/12，7万；

3.国家自然科学基金青年科学基金项目，血小板膜包被仿生纳米前药用于高效靶向抑制血管再狭窄的研究，2017/01-2019/12，20万；

（四）参与科研项目：

1. 国家重点研发计划，BRS 降解控制中血管内皮和中层平滑肌细胞表型调控和逆转钙化技术研究，2016/07-20120/12，100万；

2. 国家自然科学基金重点项目，基于多肽-蛋白质药物聚集体构建新型控释系统的研究，2016/01-2020/12，300万；

3.国家自然科学基金青年科学基金项目，导电聚合物界面性质的协同作用选择性调控特定细胞行为的研究，2016/01-2018/12，21万；

4.国家自然科学基金青年科学基金项目，导电聚合物界面性质的协同作用选择性调控特定细胞行为的研究，2016/01-2018/12，21万；

5.国家自然科学基金面上项目，唾液获得性膜蛋白启迪的牙体硬组织原位修复材料的研究，2016/01-2019/12，63万；

6.国家自然科学基金青年科学基金项目， EGCG-ACP纳米复合物修复酸蚀损伤牙本质的双重作用及分子机制研究，2015/01-2017/12，23万；